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Sandro Da Mesquita conecta profile

Sandro Da Mesquita

Sandro Da Mesquita is Postdoctoral Researcher in the Kipnis Lab, Department of Neuroscience and Center for Brain Immunology and Glia, University of Virginia School of Medicine (USA). In 2015, he finished his PhD in Health Sciences, Aging and Alzheimer’s Disease from University of Minho (Braga, Portugal), where held several research positions at Life and Health Sciences Research Institute, University of Minho (Portugal) from 2009 to 2016. His current research is focused in understanding how meningeal lymphatic function affects the drainage of CSF components and if progressive dysfunction of meningeal lymphatic drainage in the aged CNS might predispose for neurodegenerative disorders like Alzheimer’s disease. He is currently using a diverse set of surgical, biochemical, imaging and gene expression screening techniques to further unveil the functional connection between the newly described meningeal lymphatics and the CNS, and to figure out how these two systems work in tandem to modulate the CSF-ISF recirculation and CNS homeostasis. Additionally, he is examining the changes in meningeal lymphatics in mouse models of aging and of Alzheimer’s disease and developing therapeutic strategies aimed at ameliorating brain amyloid pathology and cognitive impairment by boosting meningeal lymphatic function. Sandro Da Mesquita has published several papers in international peer reviewed (ISI) journals, including in the prestigious journal Nature. His discovery about the role of the brain’s cleaning system in aging and Alzheimer’s disease has been recognized by the National Institutes of Health as one of 2018’s most promising medical advances, and was also saluted by Forbes in a year-end article.

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Email: sd8tf@virginia.edu